Candis Cayne is returning to ABC.

The actress will play a trans patient who checks into Grey Sloan Memorial Hospital, for a "groundbreaking" vaginaoplasty surgery, in a multi-episode arc on this season of Grey's Anatomy.

According to The Hollywood Reporter, Cayne's character was inspired by a story the show's writers read about Hayley Anthony, a trans woman who helped Jess Ting, the director of surgery at the Center for Transgender Medicine and Surgery at Mount Sinai, create a revolutionary new procedure for vaginoplasty surgeries.

"[The surgery] revolutionizes the making of a vagina and we thought that was a really cool story and Candis is playing a character inspired by something we read," said Grey's Anatomy showrunner Krista Vernoff.

Cayne's will not be the first trans storyline this season. Out trans actor Alex Blue Davis—who plays intern Dr. Casey Parker—came out as trans to Bailey (Chandra Wilson) after he saved the hospital's computer system from a hacker.

"What's cool about the show, the episode and Krista's vision for this character is he's about way more than being trans," said Davis.

This will be Cayne's latest TV role after recently appearing on The Magicians, Transparent and I Am Cait. In 2007 she made TV history when she became the first trans actress to portray a recurring trans character on primetime television in the series, Dirty Sexy Money.